The optimal regional irradiation volume for breast cancer patients: A comprehensive systematic review and network meta-analysis of published studies.

ABSTRACT:

Background

Currently, the optimal adjuvant regional nodal irradiation (RNI) volume for breast cancer (BC) remained controversial. We aimed to define the optimal RNI treatment volume for BC by using a comprehensive network meta-analysis (NMA) of published studies.

Materials and methods

PubMed, Embase, Medline, and Cochrane Central Register of Controlled Trials were searched from database inception to 30 May 2022. Studies assessing different adjuvant RNI volumes for BC were eligible for inclusion. The primary outcome was overall survival (OS), and secondary outcome was disease-free survival (DFS) and distant-metastasis-free survival (DMFS).

Results

A total of 29,640 BC patients from twenty studies were included. The pooled hazard ratio demonstrated that internal mammary

SUBMITTER: Qi WX 

PROVIDER: S-EPMC9927229 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature