PfSET2 Is Involved in Genome Organization of Var Gene Family in Plasmodium falciparum.

ABSTRACT: The three-dimensional (3D) genome structure of human malaria parasite Plasmodium falciparum is highly organized and plays important roles in regulating coordinated expression patterns of specific genes such as virulence genes which are involved in antigenic variation and immune escape. However, the molecular mechanisms that control 3D genome of the parasite remain elusive. Here, by analyzing genome organization of P. falciparum, we identify high-interacting regions (HIRs) with strong chromatin interactions at telomeres and virulence genes loci. Specifically, HIRs are highly enriched with repressive histone marks (H3K36me3 and H3K9me3) and form the transcriptional repressive center. Deletion of PfSET2, which controls H3K36me3 level, results in marked reduction of both intrachromosoma

SUBMITTER: Cao X 

PROVIDER: S-EPMC9927267 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature