Interaction between Host and Microbes in the Semen of Patients with Idiopathic Nonobstructive Azoospermia.

ABSTRACT: Men with nonobstructive azoospermia (NOA) face the dual problems of low sperm count and low sperm quality. Most men with NOA without a clear cause are classified as having idiopathic NOA (iNOA). Previous studies found that microbes exist in semen, and the semen microbes of NOA men are different from those of normal men. However, the relevant mechanism is not clear. In this study, we answered the three questions of "who is there," "what is it doing," and "who is doing it" by combining 16s rRNA, nontargeted metabolome detection and metabolite traceability analysis. We found that the composition and interaction of seminal plasma microbes in the iNOA group changed. Metabolite traceability analysis and metabolic pathway analysis revealed that microbial abnormalities in the NOA group were closel

SUBMITTER: Chen P 

PROVIDER: S-EPMC9927269 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature