Intracellular Transposition of Mobile Genetic Elements Associated with the Colistin Resistance Gene <i>mcr-1</i>.

ABSTRACT: Mobile colistin resistance (mcr) genes are often located on conjugative plasmids, where their association with insertion sequences enables intercellular and intracellular dissemination throughout bacterial replicons and populations. Multiple mcr genes have been discovered in every habitable continent, in many bacterial species, on both plasmids and integrated into the chromosome. Previously, we showed the intercellular transfer of mcr-1 on an IncI1 plasmid, pMCR-E2899, between strains of Escherichia coli. Characterizing the intracellular dynamics of mcr-1 transposition and recombination would further our understanding of how these important genes move through bacterial populations and whether interventions can be put in place to stop their spread. In this study,

SUBMITTER: Goodman RN 

PROVIDER: S-EPMC9927407 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature