Diverse Partners of the Partitioning ParB Protein in Pseudomonas aeruginosa.

ABSTRACT: In the majority of bacterial species, the tripartite ParAB-parS system, composed of an ATPase (ParA), a DNA-binding protein (ParB), and its target parS sequence(s), assists in the chromosome partitioning. ParB forms large nucleoprotein complexes at parS(s), located in the vicinity of origin of chromosomal replication (oriC), which after replication are subsequently positioned by ParA in cell poles. Remarkably, ParA and ParB participate not only in the chromosome segregation but through interactions with various cellular partners they are also involved in other cell cycle-related processes, in a species-specific manner. In this work, we characterized Pseudomonas aeruginosa ParB interactions with the cognate ParA, showing that the N-terminal motif of ParB is requi

SUBMITTER: Kawalek A 

PROVIDER: S-EPMC9927451 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature