Characteristics and Correlations of the Oral and Gut Fungal Microbiome with Hypertension.

ABSTRACT: The mycobiome is an essential constituent of the human microbiome and is associated with various diseases. However, the role of oral and gut fungi in hypertension (HTN) remains largely unexplored. In this study, saliva, subgingival plaques, and feces were collected from 36 participants with HTN and 24 healthy controls for metagenomic sequencing. The obtained sequences were analyzed using the Kraken2 taxonomic annotation pipeline to assess fungal composition and diversity. Correlations between oral and gut fungi and clinic parameters, between fungi within the same sample types, and between different sample types were identified by Spearman's correlation analysis. Overall, the subgingival fungal microbiome had substantially higher alpha diversity than the salivary and fecal fungal microbiome

SUBMITTER: Chen BY 

PROVIDER: S-EPMC9927468 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature