In Vitro Activity of the Novel Antifungal Olorofim against Scedosporium and Lomentospora prolificans.

ABSTRACT: Scedosporium spp. and Lomentospora prolificans are an emerging group of fungi refractory to current antifungal treatments. These species largely affect immunocompromised individuals but can also be lung colonizers in cystic fibrosis patients. Although Scedosporium apiospermum is thought to be the predominant species, the group has been expanded to a species complex. The distribution of species within the S. apiospermum species complex and other closely related species in the United States is largely unknown. Here, we used β-tubulin and ITS sequences to identify 37 Scedosporium isolates to the species level. These Scedosporium isolates as well as 13 L. prolificans isolates were tested against a panel of nine antifungal drugs, including the first in novel c

SUBMITTER: Georgacopoulos O 

PROVIDER: S-EPMC9927477 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature