Gut Microbial Succession Patterns and Metabolic Profiling during Pregnancy and Lactation in a Goat Model.

ABSTRACT: The maternal gut microbiome affects the duration of pregnancy, delivery, and lactation. It also coordinates the stability of maternal metabolism by regulating and modulating inflammatory cytokines and reproductive hormones. This has been shown in several species; however, the situation in ruminants remains a black box. Here, we aimed to elucidate the relationship between the hindgut microbiota, metabolism, and reproductive hormones in domestic goats (Capra hircus) during nonpregnancy, pregnancy, and lactation stages. The hindgut microbiota was altered during these three stages, with a drastic decrease in the abundance of Family_XIII_AD3011_group in the second and third trimesters of pregnancy. Additionally, a decline in the abundance of Christensenellaceae_R-7_group and Tu

SUBMITTER: Zhang K 

PROVIDER: S-EPMC9927511 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature