Photostress Recovery Time as a Potential Predictive Biomarker for Age-Related Macular Degeneration.

ABSTRACT:

Purpose

The purpose of this study was to assess recovery time following photostress and its association with age-related macular degeneration (AMD) cross-sectionally and longitudinally in an elderly population-based cohort.

Methods

We analyzed photostress recovery time (PRT) and AMD in >1800 AugUR study participants aged 70+ years. On color fundus images from baseline and 3-year follow-up, presence of AMD was graded manually (Three Continent AMD Consortium Severity Scale). Visual acuity (VA) was assessed via Early Treatment Diabetic Retinopathy Study (ETDRS) charts. After a 30-second bleaching of the macular region via direct ophthalmoscope, PRT was measured as the seconds to regain VA.

Results

First, we analyzed 1208 AugUR participants cross-sectionally (288 with ear

SUBMITTER: Brandl C 

PROVIDER: S-EPMC9927759 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature