Abnormal gait and motor cortical processing in drug-resistant juvenile myoclonic epilepsy.

ABSTRACT:

Background

Juvenile myoclonic epilepsy (JME) is characterized by generalized seizures. Nearly 30% of JME patients are drug-resistant (DR-JME), indicating a widespread cortical dysfunction. Walking is an important function that necessitates orchestrated coordination of frontocentral cortical regions. However, gait alterations in JME have been scarcely investigated. Our aim was to assess changes in gait and motor-evoked responses in DR-JME patients.

Methods

Twenty-nine subjects (11 JME drug-responder, 8 DR-JME, and 10 healthy controls) underwent a gait analyses during usual walking and dual-task walking. Later, subjects underwent 64-channel EEG recordings while performing a simple motor task. We calculated the motor-evoked current source densities (CSD) at a priori chosen cort

SUBMITTER: Maidan I 

PROVIDER: S-EPMC9927833 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature