Whole-brain DTI parameters associated with tau protein and hippocampal volume in Alzheimer's disease.

ABSTRACT: The causes of the neurodegenerative processes in Alzheimer's disease (AD) are not completely known. Recent studies have shown that white matter (WM) damage could be more severe and widespread than whole-brain cortical atrophy and that such damage may appear even before the damage to the gray matter (GM). In AD, Amyloid-beta (Aβ₄₂ ) and tau proteins could directly affect WM, spreading across brain networks. Since hippocampal atrophy is common in the early phase of disease, it is reasonable to expect that hippocampal volume (HV) might be also related to WM integrity. Our study aimed to evaluate the integrity of the whole-brain WM, through diffusion tensor imaging (DTI) parameters, in mild AD and amnestic mild cognitive impairment (aMCI) due to AD (with Aβ₄₂ alteration i

SUBMITTER: Magalhaes TNC 

PROVIDER: S-EPMC9927845 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature