Reduced methylation correlates with diabetic nephropathy risk in type 1 diabetes.

ABSTRACT: Diabetic nephropathy (DN) is a polygenic disorder with few risk variants showing robust replication in large-scale genome-wide association studies. To understand the role of DNA methylation, it is important to have the prevailing genomic view to distinguish key sequence elements that influence gene expression. This is particularly challenging for DN because genome-wide methylation patterns are poorly defined. While methylation is known to alter gene expression, the importance of this causal relationship is obscured by array-based technologies since coverage outside promoter regions is low. To overcome these challenges, we performed methylation sequencing using leukocytes derived from participants of the Finnish Diabetic Nephropathy (FinnDiane) type 1 diabetes (T1D) study (n = 39) that was

SUBMITTER: Khurana I 

PROVIDER: S-EPMC9927943 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature