A core UPS molecular complement implicates unique endocytic compartments at the parasite-host interface in Giardia lamblia.

ABSTRACT: Unconventional protein secretion (UPS) plays important roles in cell physiology. In contrast to canonical secretory routes, UPS does not generally require secretory signal sequences and often bypasses secretory compartments such as the ER and the Golgi apparatus. Giardia lamblia is a protist parasite with reduced subcellular complexity which releases several proteins, some of them virulence factors, without canonical secretory signals. This implicates UPS at the parasite-host interface. No dedicated machinery nor mechanism(s) for UPS in Giardia are currently known, although speculations on the involvement of endocytic organelles called PV/PECs, have been put forth. To begin to address the question of whether PV/PECs are implicated in virulence-associated UPS and to define the composition o

SUBMITTER: Balmer EA 

PROVIDER: S-EPMC9928461 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature