Brain-clinical signatures for vagus nerve stimulation response.

ABSTRACT:

Aim

Vagus nerve stimulation (VNS) is a valuable treatment for drug-resistant epilepsy (DRE) without the indication of surgical resection. The clinical heterogeneity of DRE has limited the optimal indication of choice and diagnosis prediction. The study aimed to explore the correlations of brain-clinical signatures with the clinical phenotype and VNS responsiveness.

Methods

A total of 89 DRE patients, including VNS- (n = 44) and drug-treated (n = 45) patients, were retrospectively recruited. The brain-clinical signature consisted of demographic information and brain structural deformations, which were measured using deformation-based morphometry and presented as Jacobian determinant maps. The efficacy and presurgical differences between these two cohorts were compared. Then,

SUBMITTER: Guo Z 

PROVIDER: S-EPMC9928539 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature