Auditory-limbic-cerebellum interactions and cognitive impairments in noise-induced hearing loss.

ABSTRACT:

Aims

This study aimed to explore the neural substrate of hearing loss-related central nervous system in rats and its correlation with cognition.

Methods

We identified the neural mechanism for these debilitating abnormalities by inducing a bilateral hearing loss animal model using intense broadband noise (122 dB of broadband noise for 2 h) and used the Morris water maze test to characterize the behavioral changes at 6 months post-noise exposure. Functional magnetic resonance imaging (fMRI) was conducted to clarify disrupted functional network using bilateral auditory cortex (ACx) as a seed. Structural diffusion tensor imaging (DTI) was applied to illustrate characteristics of fibers in ACx and hippocampus. Pearson correlation was computed behavioral tests and other features.<

SUBMITTER: Xu XM 

PROVIDER: S-EPMC9928548 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature