Alpha-Asarone modulates kynurenine disposal in muscle and mediates resilience to stress-induced depression via PGC-1α induction.

ABSTRACT:

Introduction

Kynurenine (KYN) accumulation in periphery induces brain injury, responsible for depression. α-Asarone is a simple phenylpropanoids that exerts beneficial effects on central nervous system. However, the effect of α-asarone on periphery is unexplored.

Aims

Here, we investigated its protective role against depression from the aspect of KYN metabolism in skeletal muscle.

Methods

The antidepressant effects of α-asarone were evaluated in chronic mild stress (CMS) and muscle-specific PGC-1α-deficient mice. The effects of KYN metabolism were determined in mice and C2C12 myoblasts.

Results

α-Asarone exerted antidepressant effects in CMS and KYN-challenged mice via modulating KYN metabolism. In myoblasts, α-asarone regulated PGC-1α induction via cAMP/CREB s

SUBMITTER: Yan L 

PROVIDER: S-EPMC9928554 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature