Polarized branched Actin modulates cortical mechanics to produce unequal-size daughters during asymmetric division.

ABSTRACT: The control of cell shape during cytokinesis requires a precise regulation of mechanical properties of the cell cortex. Only few studies have addressed the mechanisms underlying the robust production of unequal-sized daughters during asymmetric cell division. Here we report that unequal daughter-cell sizes resulting from asymmetric sensory organ precursor divisions in Drosophila are controlled by the relative amount of cortical branched Actin between the two cell poles. We demonstrate this by mistargeting the machinery for branched Actin dynamics using nanobodies and optogenetics. We can thereby engineer the cell shape with temporal precision and thus the daughter-cell size at different stages of cytokinesis. Most strikingly, inverting cortical Actin asymmetry causes an inversion of daught

SUBMITTER: Daeden A 

PROVIDER: S-EPMC9928585 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature