Survival Outcomes of Patients With Tropomyosin Receptor Kinase Fusion-Positive Cancer Receiving Larotrectinib Versus Standard of Care: A Matching-Adjusted Indirect Comparison Using Real-World Data.

ABSTRACT:

Purpose

Larotrectinib, a highly specific tropomyosin receptor kinase (TRK) inhibitor, previously demonstrated high response rates in single-arm trials of patients with TRK fusion-positive cancer, but there are limited data on comparative effectiveness against standard-of-care (SoC) regimens used in routine health care practice, before widespread adoption of TRK inhibitors as SoC for TRK fusion-positive cancers. Matching-adjusted indirect comparison, a validated methodology that balances population characteristics to facilitate cross-trial comparisons, was used to compare the overall survival (OS) of larotrectinib versus non-TRK-inhibitor SoC.

Materials and methods

Individual patient data from three larotrectinib trials (ClinicalTrials.gov identifiers: NCT02122913, NCT0263768

SUBMITTER: Bokemeyer C 

PROVIDER: S-EPMC9928633 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature