Inhibitory effects of Patchouli alcohol on the early lifecycle stages of influenza A virus.

ABSTRACT:

Background

The antiviral activity and underlying mechanism of Patchouli alcohol remain unclear.

Methods

This study evaluated the cytotoxicity, optimal methods for drug administration, anti-influenza A activity of Patchouli alcohol. The antiviral mechanism of Patchouli alcohol was also assessed via qRT-PCR, western blot, hemagglutination inhibiting (HAI) assay, and hemolysis inhibiting assay.

Results

Patchouli alcohol was shown to have low cytotoxicity and its strongest antiviral effect was associated with premixed administration. Patchouli alcohol inhibited virus replication during the early lifecycle stages of influenza A virus infection and specifically prevented expression of the viral proteins, HA and NP. In both the HAI and hemolysis inhibiting assays, Pat

SUBMITTER: Fan Y 

PROVIDER: S-EPMC9928722 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature