Naegleria genus pangenome reveals new structural and functional insights into the versatility of these free-living amoebae.

ABSTRACT:

Introduction

Free-living amoebae of the Naegleria genus belong to the major protist clade Heterolobosea and are ubiquitously distributed in soil and freshwater habitats. Of the 47 Naegleria species described, N. fowleri is the only one being pathogenic to humans, causing a rare but fulminant primary amoebic meningoencephalitis. Some Naegleria genome sequences are publicly available, but the genetic basis for Naegleria diversity and ability to thrive in diverse environments (including human brain) remains unclear.

Methods

Herein, we constructed a high-quality Naegleria genus pangenome to obtain a comprehensive catalog of genes encoded by these amoebae. For this, we first sequenced, assembled, and annotated six new Naegleria gen

SUBMITTER: Dereeper A 

PROVIDER: S-EPMC9928731 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature