Rationale and design for the myocardial ischemia and transfusion (MINT) randomized clinical trial.

ABSTRACT:

Background

Accumulating evidence from clinical trials suggests that a lower (restrictive) hemoglobin threshold (<8 g/dL) for red blood cell (RBC) transfusion, compared with a higher (liberal) threshold (≥10 g/dL) is safe. However, in anemic patients with acute myocardial infarction (MI), maintaining a higher hemoglobin level may increase oxygen delivery to vulnerable myocardium resulting in improved clinical outcomes. Conversely, RBC transfusion may result in increased blood viscosity, vascular inflammation, and reduction in available nitric oxide resulting in worse clinical outcomes. We hypothesize that a liberal transfusion strategy would improve clinical outcomes as compared to a more restrictive strategy.

Methods

We will enroll 3500 patients with acute MI (type 1, 2, 4b

SUBMITTER: Carson JL 

PROVIDER: S-EPMC9928777 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature