The added prognostic values of baseline PET dissemination parameter in patients with angioimmunoblastic T-cell lymphoma.

ABSTRACT: To explore the prognostic values of baseline 2-deoxy-2-[¹⁸F] fluoro-D-glucose (FDG) positron emission tomography/computed tomography (PET/CT) dissemination parameter in angioimmunoblastic T-cell lymphoma (AITL) and its added values to total metabolic tumour volume (TMTV). Eighty-one AITL patients with at least two FDG-avid lesions in baseline PET/CT were retrospectively included. PET parameters including TMTV and the distance between the two lesions that are the furthest apart (Dmax) were obtained. Univariate Cox analysis showed that both Dmax and TMTV were risk factors for progression-free survival (PFS) and overall survival (OS). Multivariate Cox analysis models of different combinations showed that high Dmax (> 65.7 cm) could independently predict both PFS and OS, while high

SUBMITTER: Gong H 

PROVIDER: S-EPMC9928789 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature