Investigating and modeling positron emission tomography factors associated with large cell transformation from low-grade lymphomas.

ABSTRACT: Low-grade lymphomas have a 1%-3% annual risk of transformation to a high-grade histology, and prognostic factors remain undefined. We set to investigate the role of positron emission tomography (PET) metrics in identification of transformation in a retrospective case-control series of patients matched by histology and follow-up time. We measured PET parameters including maximum standard uptake value (SUV-max) and total lesion glycolysis (TLG), and developed a PET feature and lactate dehydrogenase (LDH)-based model to identify transformation status within discovery and validation cohorts. For our discovery cohort, we identified 53 patients with transformation and 53 controls with a similar distribution of follicular lymphoma (FL). Time to transformation and control follow-up time was simila

SUBMITTER: Obeid JP 

PROVIDER: S-EPMC9928791 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature