Prospective comprehensive profiling of immune responses to COVID-19 vaccination in patients on zanubrutinib therapy.
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ABSTRACT:
SUBMITTER: Nguyen THO
PROVIDER: S-EPMC9928803 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Publications
Prospective comprehensive profiling of immune responses to COVID-19 vaccination in patients on zanubrutinib therapy.
Nguyen Thi H O THO Lim Chhay C Lasica Masa M Whitechurch Ashley A Tennakoon Surekha S Saunders Natalie R NR Allen Lilith F LF Rowntree Louise C LC Chua Brendon Y BY Kedzierski Lukasz L Tan Hyon-Xhi HX Wheatley Adam K AK Kent Stephen J SJ Karapanagiotidis Theo T Nicholson Suellen S Williamson Deborah A DA Slavin Monica A MA Tam Constantine S CS Kedzierska Katherine K Teh Benjamin W BW
EJHaem 20230120 1
Zanubrutinib-treated and treatment-naïve patients with chronic lymphocytic leukaemia (CLL) or Waldenstrom's macroglobulinaemia were recruited in this prospective study to comprehensively profile humoral and cellular immune responses to COVID-19 vaccination. Overall, 45 patients (median 72 years old) were recruited; the majority were male (71%), had CLL (76%) and were on zanubrutinib (78%). Seroconversion rates were 65% and 77% following two and three doses, respectively. CD4<sup>+</sup> and CD8< ...[more]
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