Safety and clinical efficacy of linezolid in children: a systematic review and meta-analysis.

ABSTRACT:

Background

We aimed to evaluate the tolerability and efficacy of linezolid in children for treating suspected and diagnosed Gram-positive bacterial infections.

Methods

A systematic literature search was conducted up to April 23, 2021, using linezolid and its synonyms as search terms. Two reviewers independently identified and extracted relevant randomized controlled trials and prospective cohort studies. The extracted studies were included in a single-rate meta-analysis of adverse events and clinical outcomes using random-effects models.

Results

A total of 1082 articles were identified, and nine studies involving 758 children were included in the meta-analysis. The overall proportion of adverse events was 8.91% [95% confidence interval (CI) = 1.64%-36.52%], with diarr

SUBMITTER: Shi Y 

PROVIDER: S-EPMC9928924 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature