Prenatal methadone exposure selectively alters protein expression in primary motor cortex: Implications for synaptic function.

ABSTRACT: As problematic opioid use has reached epidemic levels over the past 2 decades, the annual prevalence of opioid use disorder (OUD) in pregnant women has also increased 333%. Yet, how opioids affect the developing brain of offspring from mothers experiencing OUD remains understudied and not fully understood. Animal models of prenatal opioid exposure have discovered many deficits in the offspring of prenatal opioid exposed mothers, such as delays in the development of sensorimotor function and long-term locomotive hyperactivity. In attempt to further understand these deficits and link them with protein changes driven by prenatal opioid exposure, we used a mouse model of prenatal methadone exposure (PME) and preformed an unbiased multi-omic analysis across many sensoriomotor brain regions know

SUBMITTER: Haggerty DL 

PROVIDER: S-EPMC9928955 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature