NAMPT and NAPRT serum levels predict response to anti-TNF therapy in inflammatory bowel disease.

ABSTRACT:

Background

Nicotinamide phosphoribosyltransferase (NAMPT) and nicotinic acid phosphoribosyl transferase (NAPRT) are key intracellular enzymes that participate in the biosynthesis on NAD but have also been shown to be released as proinflammatory cytokines. A number of reports have shown that circulating NAMPT is increased in serum of patients with inflammatory disorders, including inflammatory bowel diseases (IBD), while nothing is known regarding circulating NAPRT and the presence of both cytokines in IBD patient stools. In the present study, we evaluated eNAMPT and eNAPRT levels in a large cohort of IBD patients not on biological therapy and in a subset that then was prescribed biologics.

Methods

We conducted a retro-perspective study on 180 patients, of which 111 underwent

SUBMITTER: Colombo G 

PROVIDER: S-EPMC9928959 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature