Robustness of a multivariate composite score when evaluating distress of animal models for gastrointestinal diseases.

ABSTRACT: The fundament of an evidence-based severity assessment in laboratory animal science is reliable distress parameters. Many readouts are used to evaluate and determine animal distress and the severity of experimental procedures. Therefore, we analyzed four distinct parameters like the body weight, burrowing behavior, nesting, and distress score in the four gastrointestinal animal models (pancreatic ductal adenocarcinoma (PDA), pancreatitis, CCl₄ intoxication, and bile duct ligation (BDL)). Further, we determined the parameters' robustness in various experimental subgroups due to slight variations like drug treatment or telemeter implantations. We used non-parametric bootstrapping to get robust estimates and 95% confidence intervals for the experimental groups. It was found that th

SUBMITTER: Talbot SR 

PROVIDER: S-EPMC9929045 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature