Modulation of transcription factor dynamics allows versatile information transmission.

ABSTRACT: Cells detect changes in their environment and generate responses, often involving changes in gene expression. In this paper we use information theory and a simple transcription model to analyze whether the resulting gene expression serves to identify extracellular stimuli and assess their intensity when they are encoded in the amplitude, duration or frequency of pulses of a transcription factor's nuclear concentration (or activation state). We find, for all cases, that about three ranges of input strengths can be distinguished and that maximum information transmission occurs for fast and high activation threshold promoters. The three input modulation modes differ in the sensitivity to changes in the promoters parameters. Frequency modulation is the most sensitive and duration modulation, t

SUBMITTER: Givre A 

PROVIDER: S-EPMC9929046 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature