A longitudinal microstructural MRI dataset in healthy C57Bl/6 mice at 9.4 Tesla.

ABSTRACT: Multimodal microstructural MRI has shown increased sensitivity and specificity to changes in various brain disease and injury models in the preclinical setting. Here, we present an in vivo longitudinal dataset, including a subset of ex vivo data, acquired as control data and to investigate microstructural changes in the healthy mouse brain. The dataset consists of structural T2-weighted imaging, magnetization transfer ratio and saturation imaging, and advanced quantitative diffusion MRI (dMRI) methods. The dMRI methods include oscillating gradient spin echo (OGSE) dMRI and microscopic anisotropy (μA) dMRI, which provide additional insight by increasing sensitivity to smaller spatial scales and disentangling fiber orientation dispersion from true microstructural changes, respectively. The t

SUBMITTER: Rahman N 

PROVIDER: S-EPMC9929084 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature