Detection of iron oxide nanoparticle (IONP)-labeled stem cells using quantitative ultrashort echo time imaging: a feasibility study.

ABSTRACT:

Background

In this study, we investigated the feasibility of quantitative ultrashort echo time (qUTE) magnetic resonance (MR) imaging techniques in the detection and quantification of iron oxide nanoparticle (IONP)-labeled stem cells.

Methods

A stem cell phantom containing multiple layers of unlabeled or labeled stem cells with different densities was prepared. The phantom was imaged with quantitative UTE (qUTE) MR techniques [i.e., UTE-T₁ mapping, UTE-T₂* mapping, and UTE-based quantitative susceptibility mapping (UTE-QSM)] as well as with a clinical T₂ mapping sequence on a 3T clinical MR system. For T₁ mapping, a variable flip angle (VFA) method based on actual flip angle imaging (AFI) technique was utilized. For T₂*

SUBMITTER: Athertya JS 

PROVIDER: S-EPMC9929408 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature