Functional-structural large-scale brain networks are correlated with neurocognitive impairment in acute mild traumatic brain injury.

ABSTRACT:

Background

This study was conducted to investigate topological changes in large-scale functional connectivity (FC) and structural connectivity (SC) networks in acute mild traumatic brain injury (mTBI) and determine their potential relevance to cognitive impairment.

Methods

Seventy-one patients with acute mTBI (29 males, 42 females, mean age 43.54 years) from Nanjing First Hospital and 57 matched healthy controls (HC) (33 males, 24 females, mean age 46.16 years) from the local community were recruited in this prospective study. Resting-state functional magnetic resonance imaging (rs-fMRI) and diffusion tensor imaging (DTI) were acquired within 14 days (mean 3.29 days) after the onset of mTBI. Then, large-scale FC and SC networks with 116 regions from the automated anatomical

SUBMITTER: Liu Y 

PROVIDER: S-EPMC9929413 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature