Age- and sex-related differences in cortical morphology and their relationships with cognitive performance in healthy middle-aged and older adults.

ABSTRACT:

Background

The impacts of age and sex on brain structures related to cognitive function may be important for understanding the role of aging in Alzheimer disease for both sexes. We intended to investigate the age and sex differences of cortical morphology in middle-aged and older adults and their relationships with the decline of cognitive function.

Methods

In this cross-sectional study, we examined the cortical morphology in 204 healthy middle-aged and older adult participants aged 45 to 89 years using structural magnetic resonance imaging (sMRI) data from the Dallas Lifespan Brain Study data set. Brain cortical thickness, surface complexity, and gyrification index were analyzed through a completely automated surface-based morphometric analysis using the CAT12 toolbox. Furt

SUBMITTER: Cui D 

PROVIDER: S-EPMC9929420 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature