Network segregation in aging females and evaluation of the impact of sex steroid hormones.

ABSTRACT: Males and females show differential patterns in connectivity in resting-state networks (RSNs) during normal aging, from early adulthood to late middle age. Age-related differences in network integration (effectiveness of specialized communication at the global network level) and segregation (functional specialization at the local level of specific brain regions) may also differ by sex. These differences may be due at least in part to endogenous hormonal fluctuation, such as that which occurs in females during midlife with the transition to menopause when levels of estrogens and progesterone drop markedly. A limited number of studies that have investigated sex differences in the action of steroid hormones in brain networks. Here we investigated how sex steroid hormones relate to age-network

SUBMITTER: Hicks TH 

PROVIDER: S-EPMC9929548 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature