LncRNA GAS5 suppression of the malignant phenotype of ovarian cancer via the miR-23a-WT1 axis

ABSTRACT:

Background

Growth arrest-specific 5 (GAS5) is a long noncoding RNA (lncRNA) that regulates cell viability. GAS5 lncRNA has been shown to decrease colorectal and breast cancer carcinogenesis. Although the function and mechanisms related to lncRNA GAS5 in the development of ovarian cancer (OC) remains unclear. The goal of this study was to clarify the essential functions of lncRNA GAS5 in regulating OC progression and its underlying mechanism.

Methods

Relative levels of lncRNA GAS5 in OC and normal ovarian tissues were identified by quantitative real-time polymerase chain reaction (qRT-PCR). The regulatory effects of lncRNA GAS5 on the proliferation and apoptosis of SK-OV-3 cells were evaluated. Moreover, bioinformatics tools were used to predict a novel target [microRNA (m

SUBMITTER: Zhou L 

PROVIDER: S-EPMC9929739 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature