Electroacupuncture ameliorates surgery-induced spatial memory deficits by promoting mitophagy in rats.

ABSTRACT:

Background

This study sought to explore the mechanism underlying the therapeutic effects of electroacupuncture (EA) on spatial memory deficits caused by surgery.

Methods

Hepatic apex resection was performed under propofol-based total intravenous anesthesia. Male Sprague-Dawley rats were subjected to EA treatment or EA + mitochondrial division inhibitor-1 (mdivi-1) treatment once a day for three consecutive days after surgery. The Morris water maze test was used to evaluate the spatial memory of the rats after surgery. Tissue from the hippocampus of each rat was frozen and used for transcriptomic and proteomic analyses to identify potential targets for EA treatment. Western blotting was used to confirm the protein expression levels. The levels of reactive oxygen species (ROS)

SUBMITTER: Guo J 

PROVIDER: S-EPMC9929787 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature