Screening and identification of susceptibility genes for osteosarcoma based on bioinformatics analysis.

ABSTRACT:

Background

Gene play an important role in malignant tumors. However, there is still insufficient research on genetic variations in osteosarcoma (OS) patients. Therefore, we aimed to analyze the gene expression profile of OS using bioinformatics and to explore the pathogenesis of OS at the molecular level.

Methods

The gene chip dataset of OS samples was downloaded from the Gene Expression Omnibus (GEO) database for screening differentially expressed genes (DEGs). The R language clusterProfiler software package was used to perform Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis for DEGs. The central node proteins of the protein interaction network were analyzed by the Search Tool for the Retrieval of Interacting Genes/Proteins

SUBMITTER: Lu Z 

PROVIDER: S-EPMC9929789 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature