Expression analysis of human glioma susceptibility gene and P53 in human glioma and its clinical significance based on bioinformatics.

ABSTRACT:

Background

The exact mechanism of glioblastoma multiforme (GBM) remains unclear. This study was to clarify the expression of P53 in glioma and its molecular mechanism, and to explore the possibility of P53 as a potential therapeutic target of glioma and its clinical application value, so as to provide a new theoretical basis for the treatment of glioma.

Methods

Firstly, a dataset was established to analyze the expression of P53 in different stages of glioma and its relationship with prognosis by using The Cancer Genome Atlas (TCGA) database, RNA-seq data, and survival data of glioma and normal control samples in gene expression profiling and interactive analysis (GEPIA). The genes co-expressed with P53 were screened out, their differential express

SUBMITTER: Li B 

PROVIDER: S-EPMC9929792 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature