Landscape of costimulatory molecule signature in breast cancer and its prognostic significance.

ABSTRACT:

Background

Breast cancer (BRCA) is the most common malignant tumor in the world. Because of its substantial heterogeneity, its clinical treatment is faced with various problems. Only a small number of patients can benefit from the treatment of immune checkpoint inhibitor (ICI). Costimulatory molecule signature (CMS) plays an essential role in T cell activation and antitumor immune response. Previous studies found that CMS is associated with prognosis-related immune response markers, suggesting that CMS may be a potential therapeutic target. However, the research on their function in BRCA subtype is still inadequate. Our study aims to analyze CMS in BRCA and establish an effective prognostic model.

Methods

We extracted 1,222 messenger RNA (mRNA) samples of 1,110 patients regi

SUBMITTER: Kang C 

PROVIDER: S-EPMC9929799 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature