The mitosis-related gene OIP5 is a potential biomarker in pan-cancer.

ABSTRACT:

Background

OIP5 is found at the centromere and plays an important role in recruiting centromere protein-A (CENP-A) through interacting with Holliday junction recognition protein during cell mitosis. OIP5 is considered to be a cancer-testis specific gene, but its function in tumor development remains unclear. Increased expression of OIP5 has been reported in testis as well as in different cancers; however, the underlying mechanisms remain obscure.

Methods

Data were collected from the Genotype-Tissue Expression project, the Cancer Cell Line Encyclopedia, and The Cancer Genome Atlas (TCGA) to analyze the effect of OIP5 in many common cancers. Analyses of the differential expression of OIP5 and its relationships with prognosis, the tumor microe

SUBMITTER: Pan M 

PROVIDER: S-EPMC9929809 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature