A pan-cancer analysis of the expression and prognostic significance of PDRG1.

ABSTRACT:

Background

PDRG1 are involved in various physiological regulations of cells, include cell proliferation, growth, apoptosis and cell cycle regulation, but their roles in cancer have not been clearly studied.

Methods

Firstly, we evaluated the expression and prognostic significance of PDRG1 using a pan-cancer analysis of The Cancer Genome Atlas (TCGA) and Genotypic Tissue Expression (GTEx) databases. Secondly, correlations between PDRG1 and pan-cancer immune cells, m6A methylation, tumor mutation burden (TMB), and microsatellite instability (MSI) were investigated. Finally, we explored the relationship between PDRG1 expression and clinical stage in hepatocellular carcinoma (HCC).

Results

We found that PDRG1 was significantly overexpressed in bladder urothelial carcinoma

SUBMITTER: Liu Z 

PROVIDER: S-EPMC9929825 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature