7.0T cardiac magnetic resonance imaging of right ventricular function in rats with high-altitude deacclimatization.

ABSTRACT:

Background

High-altitude deacclimatization syndrome (HADAS) is a severe public health issue. The study of the changes in right ventricular function caused by high-altitude deacclimatization (HADA) is of great significance for the prevention and treatment of HADAS.

Methods

Six-week-old, male Sprague Dawley (SD) rats were randomly divided into the plain, plateau and the HADA group. Rats in the plateau and plain group were exposed to altitudes of 3,850 and 360 m, respectively, for 12 weeks. Rats in HADA group were exposed to the plateau altitude of 3,850 m for 12 weeks and subsequently transported to the plain altitude of 360 m for 4 weeks. Right ventricular ejection fraction (RVEF), end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), and myocardial strai

SUBMITTER: Sun Y 

PROVIDER: S-EPMC9929826 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature