Systematic pan-cancer analysis identifies cGAS as an immunological and prognostic biomarker.

ABSTRACT:

Background

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus causes novel coronavirus disease 2019 (COVID-19), which is characterized by pneumonia, cytokine storms, and lymphopenia. Due to immunosuppression, cancer patients may be more susceptible to SARS-CoV-2 and have more serious complications. According to recent research, cyclic GMP-AMP synthase (cGAS) could be a potential SARS-CoV-2 sensor. However, at present, no studies have been conducted on cGAS gene alterations in pan-cancer. This study aimed to discover therapeutic implications for COVID-19-infected tumor patients by performing a comprehensive analysis of cGAS in malignant tumors.

Methods

cGAS expression matrices were obtained from The Cancer Genome Atlas (TCGA), G

SUBMITTER: Chen P 

PROVIDER: S-EPMC9929843 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature