Differential haplotype expression in class I MHC genes during SARS-CoV-2 infection of human lung cell lines.

ABSTRACT:

Introduction

Cell entry of SARS-CoV-2 causes genome-wide disruption of the transcriptional profiles of genes and biological pathways involved in the pathogenesis of COVID-19. Expression allelic imbalance is characterized by a deviation from the Mendelian expected 1:1 expression ratio and is an important source of allele-specific heterogeneity. Expression allelic imbalance can be measured by allele-specific expression analysis (ASE) across heterozygous informative expressed single nucleotide variants (eSNVs). ASE reflects many regulatory biological phenomena that can be assessed by combining genome and transcriptome information. ASE contributes to the interindividual variability associated with the disease. We aim to estimate the transcriptome-wide impact of SARS-CoV-2 infection by

SUBMITTER: Francisco Junior RDS 

PROVIDER: S-EPMC9929942 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature