Stenotrophomonas maltophilia promotes lung adenocarcinoma progression by upregulating histone deacetylase 5.

ABSTRACT:

Introduction

Lung cancer is the leading cause of cancer death worldwide, and lung adenocarcinoma (LADC) is the most common lung cancer. Lung cancer has a distinct microbiome composition correlated with patients' smoking status. However, the causal evidence of microbial impacts on LADC is largely unknown.

Methods

We investigated microbial communities' differences in Formalin-Fixed Paraffin-Embedded tissues of ever-smoke (n = 22) and never-smoke (n = 31) patients with LADC through bacterial 16S rRNA gene high-throughput sequencing. Then nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung cancer mouse model and A549 cells were used to study the effect of Stenotrophomonas maltophilia (S. maltophilia) in LADC.

Results and

SUBMITTER: Shen J 

PROVIDER: S-EPMC9929947 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature