Degradable Biocompatible Porous Microtube Scaffold for Extended Donor Cell Survival and Activity.

ABSTRACT: Cell therapy has significant therapeutic potential but is often limited by poor donor cell retention and viability at the host implantation site. Biomaterials can improve cell retention by providing cells with increased cell-cell and cell-matrix contacts and materials that allow three-dimensional cell culture to better recapitulate native cell morphology and function. In this study, we engineered a scaffold that allows for cell encapsulation and sustained three-dimensional cell culture. Since cell therapy is largely driven by paracrine secretions, the material was fabricated by electrospinning to have a large internal surface area, micrometer-thin walls, and nanoscale surface pores to allow for nutrient exchange without early cell permeation. The material is degradable, which allows for le

SUBMITTER: Nguyen H 

PROVIDER: S-EPMC9930086 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature