Supramolecular Phenylalanine-Derived Hydrogels for the Sustained Release of Functional Proteins.

ABSTRACT: Protein-based therapeutics have emerged as next-generation pharmaceutical agents for oncology, bone regeneration, autoimmune disorders, viral infections, and other diseases. The clinical application of protein therapeutics has been impeded by pharmacokinetic and pharmacodynamic challenges including off-target toxicity, rapid clearance, and drug stability. Strategies for the localized and sustained delivery of protein therapeutics have shown promise in addressing these challenges. Hydrogels are critical materials that enable these delivery strategies. Supramolecular hydrogels composed of self-assembled materials have demonstrated biocompatibility advantages over polymer hydrogels, with peptide and protein-based gels showing strong potential. However, cost is a significant drawback of peptid

SUBMITTER: Jagrosse ML 

PROVIDER: S-EPMC9930093 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature