Complement-dependent cytotoxicity of human autoantibodies against myelin oligodendrocyte glycoprotein.

ABSTRACT:

Background

The autoantibody to myelin oligodendrocyte glycoprotein (MOG), a component of the central nervous system myelin, has been identified in a subset of demyelinating diseases. However, there is no convincing evidence to support the direct pathogenic contribution of this autoantibody.

Objective

To elucidate the role of anti-MOG autoantibodies in human demyelinating disorders, we assessed the effect of autoantibodies on MOG-expressing cells.

Methods

Mammalian cells expressing the human MOG protein reacted with human anti-MOG autoantibodies in the presence or absence of complement. Sera from 86 patients and 11 healthy sera were used. We analyzed anti-MOG antibody titers, IgG subclass, and their cytotoxic ability in sera from patients with various neurological dise

SUBMITTER: Kohyama K 

PROVIDER: S-EPMC9930155 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature