The role of fatty acid desaturase 2 in multiple tumor types revealed by bulk and single-cell transcriptomes.

ABSTRACT:

Background

Previous studies have demonstrated the important role of fatty acid desaturase 2 (FADS2) in governing tumorigenesis and tumor metastasis. Although FADS2 is an essential regulator of fatty acid metabolism, its prognostic and immunotherapeutic value remains uncertain.

Methods

The role of FADS2 was investigated across different types of tumors. Besides, the relationship between FADS2 and survival prognosis, clinicopathologic features, tumor-infiltrating immune cells, immunoregulatory genes, chemokines, chemokines receptor, tumor mutational burden (TMB), and microsatellite instability (MSI) was also explored. FADS2-related genes enrichment analysis was performed to further explore the molecular function of FADS2. Finally, the relationship between FADS2 expression and

SUBMITTER: Chen E 

PROVIDER: S-EPMC9930218 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature