Cortical and subcortical morphological alteration in Angelman syndrome.

ABSTRACT:

Background

Angelman syndrome (AS) is a neurodevelopmental disorder with serious seizures. We aim to explore the brain morphometry of patients with AS and figure out whether the seizure is associated with brain development.

Methods

Seventy-three patients and 26 healthy controls (HC) underwent high-resolution structural brain MRI. Group differences between the HC group and the AS group and also between AS patients with seizure (AS-Se) and age-matched AS patients with non-seizure (AS-NSe) were compared. The voxel-based and surface-based morphometry analyses were used in our study. Gray matter volume, cortical thickness (CTH), and local gyrification index (LGI) were assessed to analyze the cortical and subcortical structure alteration in the AS brain.

Results

Firstly, com

SUBMITTER: Du X 

PROVIDER: S-EPMC9930225 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature